Further Reading - Transfusion-Related Acute Lung Injury (TRALI)

This is a comprehensive list of pertinent TRALI related articles where the reader may find further information.

Note: Canadian Blood Services offers no endorsement of and assumes no liability for the currency, accuracy, or availability of any information on these sites.

Recent Reviews

1. Marik PE, Corwin, HL. Acute lung injury following blood transfusion: Expanding the definition. Crit Care Med 2008; 36 (11): 3080- 84.
2. Triulzi, DJ. Transfusion Related Acute lung injury: current concepts for the clinician. Anesthesia and analgesia. 2009;108 (3): 770-76
3. Chapman CE, Stainsby D, Jones H, Love E, Massey E, Win N, Navarrete C, Lucas G, Soni N, Morgan C, Choo L, Cohen H, Williamson LM. Ten years of hemovigilance reports of transfusion-related acute lung injury in the United Kingdom and the impact of preferential use of male donor plasma. Transfusion. 2008 Oct 28. [Epub ahead of print]
4. Silliman CC, McLaughlin NJ.Transfusion-related acute lung injury. Blood Reviews 2006; 20(3):139-59.
5. Silliman CC, Ambruso DR, Boshkov LK. Transfusion-related acute lung injury. Blood 2005; 105(6):2266-73.
6. Bux J.Transfusion-related acute lung injury (TRALI): a serious adverse event of blood transfusion. Vox Sanguinis 2005; 89(1):1-10.
7. Shander A, Popovsky MA. Understanding the consequences of transfusion-related acute lung injury. Chest.2005; 128(5 Suppl 2):598S-604S.

Definition/Consensus articles

1. Toy P, Popovsky MA, Abraham E, Ambruso DR, Holness LG, Kopko PM, McFarland JG, Nathens AB, Silliman CC, Stroncek D; National Heart, Lung and Blood Institute Working Group on TRALI. Crit Care Med. 2005;33(4):721-6.
2. Kleinman S, Caulfield T, Chan P, Davenport R, McFarland J, McPhedran S, Meade M, Morrison D, Pinsent T, Robillard P, Slinger P. Toward an understanding of transfusion-related acute lung injury: statement of a consensus panel. Transfusion. 2004;44(12): 1774-89.
3. Skeate RC, Eastlund T. Distinguishing between transfusion related acute lung injury and transfusion associated circulatory overload. Current Opinion in Hematology. Nov 2007; 14(6):682-687.
4. Gajic O, Gropper MA, Hubmayr RD. Pulmonary edema after transfusion: How to differentiate transfusion-associated circulatory overload from transfusion-related acute lung injury. Crit Care Med. 2006;34(5) Suppl:S109-S113.

Pathogenesis

1. Jacobi KE, Wanke C, Jacobi A, Weisbach V, Hemmerling TM. Determination of Eicosaniod and cytokine production in salvaged blood, stored red blood cell concentrates, and whole blood. J Clin Anesth 12: 94-99, 2000.
2. Kopko PM, Paglieroni TG, Popovsky et al. TRALI: correlation of antigen-antibody and monocyte activation in donor-recipient pairs. Transfusion 2003;43:177-184.
3. Densmore, TL, Goodnough, LT, Ali S, Dynis M, Chaplin H. Prevalence of HLA sensitization in female apheresis donors. Transfusion 1999; 39:103-6.

Pathophysiology of TRALI

1. Silliman CC, Curtis BR, Kopko PM, et al. Donor antibodies to HNA-3a implicated in TRALI reactions prime neutrophils and cause PMN-mediated damage to human pulmonary microvascular endothelial cells in a two-event in vitro model. Blood. 2007;109(4): 1752-1755.
2. Curtis BR, McFarland JG. Mechanisms of transfusion-related acute lung injury (TRALI): anti-leukocyte antibodies. Critical Care Medicine. 2006; 34(5 Suppl):S118-23.
3. Silliman CC.The two-event model of transfusion-related acute lung injury. Critical Care Medicine. 2006; 34(5 Suppl):S124-31.
4. Toy P, Hollis-Perry KM, Jun J, Nakagawa M. Recipients of blood from a donor with multiple HLA antibodies: a lookback study of transfusion-related acute lung injury. Transfusion. 2004 Dec; 44(12): 1683-8.
5. Kopko PM. Leukocyte antibodies and biologically active mediators in the pathogenesis of transfusion-related acute lung injury. Curr Hematol Rep. 2004 Nov;3(6): 456-61.
6. Silliman CC, Bjornsen AJ, Wyman TH, Kelher M, Allard J, Bieber S, Voelkel NF. Plasma and lipids from stored platelets cause acute lung injury in an animal model. Transfusion. 2003 May; 43(5): 633-40.
7. Silliman CC, Boshkov LK, Mehdizadehkashi Z, Elzi DJ, Dickey WO, Podlosky L, Clarke G, Ambruso DR. Transfusion-related acute lung injury: epidemiology and a prospective analysis of etiologic factors. Blood. 2003; 101(2): 454-62

Prevention/Donor Management

1. Triulzi DJ, Kleinman S, Kakaiya RM et al. The effect of previous pregnancy and transfusion on HLA alloimmunization in blood donors: implications for a transfusion related acute lung injury risk reduction strategy. Transfusion 2009; 49(9):1825-35.
2. Engelfriet CP, REesink HW, Wendel S et al. Measures to prevent TRALI. Vox Sang 2007; 92 (3): 258-77.
3. AABB association bulletin #05-09
4. AABB association bulletin #06-07

For Nurses

1. Knippen MA. Transfusion-related acute lung injury. Am J Nursing. 2006;106(6):61-4.

Older Reviews

1. Kopko PM. Review: transfusion-related acute lung injury: pathophysiology, laboratory investigation, and donor management. Immunohematol. 2004; 20(2): 103-11.
2. Looney MR, Gropper MA, Matthay M. Transfusion-related acute lung injury: a review. Chest. 2004 Jul; 126(1): 249-58.
3. Webert KE, Blajchman MA. Transfusion-related acute lung injury. Transfus Med Rev. 2003 Oct; 17(4): 252-62.
4. Toy P, Gajic O. Transfusion-related acute lung injury. Anesth Analg. 2004 Dec; 99(6): 1623-4.