Post-Transfusion Purpura (PTP)

Description

Post-Transfusion Purpura (PTP) is a rare complication that results in sudden severe thrombocytopenia developing about nine
(range 1-24) days post- transfusion.

The syndrome is associated with recipient antibody to a platelet-specific antigen (usually HPA-1a developing in recipients who are HPA-1a negative). Affected women outnumber men 5:1 probably because of the requirement for pre-exposure to platelet specific antigens through pregnancy or transfusion.

The thrombocytopenia is self-limiting and usually resolves within two weeks. Implicated blood components include red blood cell, platelet concentrate, and plasma components.