Treatment - Hemostatic Abnormalities in Massive Transfusion
If the patient is actively bleeding, transfuse to keep the platelet count >50 x 109/L, INR ≤ 1.5-2.0 and fibrinogen >1.0g/L. (Head injury patients should have a platelet count >100 x 109/L). Component therapy (RBC, platelets, FFP, and cryo) should not be administered in a fixed ratio to the number of red cells transfused. It should be noted that a normothermic, normovolemic patient with a hematocrit >0.35 is more likely to maintain optimal haemostasis.