Isolated Hypotensive

Description

First described in 1996, this type of reaction is characterized by a hypotensive episode where the primary symptom is an immediate and drastic drop in blood pressure.

It has most commonly been reported following platelet transfusions.

In addition, most reported reactions have occurred with the use of negatively charged bedside leukocyte reduction filters and/or in patients on ACE inhibitor therapy. Similar reactions have been described in patients on ACE inhibitors undergoing therapeutic plasma exchange.