Treatment - Febrile Non-Hemolytic Transfusion Reactions

Treatment of FNHTR consists of treating the symptom of fever with an antipyretic such as acetominophen.

Demerol (meperidine) in small doses has also been used to treat severe shivering (rigors) that may occur in FNHTR.

Another strategy used by some clinicians is to premedicate patients who have experienced two suspected FNHTR with acetaminophen and diphenhydramine, although its efficacy has not been well studied.

If possible, further transfusions should not be given until the transfusion service has completed its serologic investigation and determined the cause of the reaction.