Treatment - Acute Non-Immune Hemolytic Transfusion Reactions

With non-immune hemolysis treatment may be unnecessary, but the patient must be monitored for significant hemolysis.

If hypotension or renal failure occurs, treatment is similar to that for acute immune-mediated hemolytic reactions. i.e., it varies with the clinical condition of each patient and focuses on treating and managing the serious sequelae of intravascular hemolysis with IV fluids, vasopressors, and diuretics.

If possible, further transfusions should not be given until the transfusion service has completed its serologic investigation and determined the cause of the reaction.