Rh Immunology Workshop - Condensed
Date:
September 15, 2009
Time:
12:00 - 13:00 Eastern
Speaker(s):
Judith L Hannon, MD FRCPC
Speaker(s):
Gwen Clarke, MD, FRCP(C)
CBS TMR Seminar September 15, 2009
Presented by Judith Hannon MD FRCPC and Gwen Clarke MD FRCPC
Title: Rh Discrepancies in Perinatal Patients – a practical approach to management
Objectives:
- Gain a basic understanding of the complexity of the Rh blood group system and the significance of the weak and variant RhD types for transfusion and prenatal testing.
- Appreciate the complexities of implementing and new test procedure in a laboratory and the need for ongoing collaboration between the testing laboratory and the physicians/hospital laboratories in managing the implementation.
Reference List:
- Flegel WA. How I manage donors and patients with a weak D phenotype. Curr Opin Hematol 2006, 13: 476-483.
- Denomme GA et al. Partial D, weak D types, and novel RHD alleles among 33,864 multiethnic patients: implications for anti-D alloimmunization and prevention. Transfusion October 2005; 45: 1554-1560.
- Garratty G. Editorial: Do we need to be more concerned about weak D antigens? Transfusion October 2005; 45: 1547-1551.
- Noizat-Pirenne F et al. Weak D phenotypes and transfusion safety: where do we stand in daily practice? Transfusion September 2007; 47: 1616-1620.
- Judd WJ et al. Reactivity of FDA-approved anti-D reagents withpartial D red blood cells. Immunohematology 2005; 21 (4): 146-148.
- Flegel WA, Denomme GA, Yazer MH. On the complexity of D antigen typing: A handy decision tree in the age of molecular blood group diagnostics. Journal of Obstetrics and Gynaecology, Canada 2007; 29(9): 746 - 752
