Dana Devine, Ph.D.

• Platelets
• Platelet Storage Lesion
• Platelet Proteomics
• Complement

The general subject areas of research expertise of this laboratory are platelet biology, complement biochemistry and blood coagulation. Our particular experimental focus in transfusion medicine is in the area of blood product processing and storage. Ongoing research projects include studies of the storage lesion of platelet concentrates and methods to improve the quality of stored platelet concentrates. Most recently, we have sought to apply leading edge technology to these research questions, in particular through the application of proteomics technology to investigations of blood products.

The research in the laboratory also includes a significant component of applied development work with projects related to practical solutions to issues arising in the manufacture of blood products including process control and quality enhancement through modification of production processes or through understanding more about the significance of the variability of donor characteristics. We have ongoing collaborations with other scientists in all of these areas as well as collaborations with companies working in the blood transfusion business.

Selected Publications:

Thon JN, Devine DV. Translation of glycoprotein IIIa in stored blood products. Transfusion 47, 2260-2270 (2007)

Devine DV, Goldman M, Englefriet P, Reesink H, Heatherington C, Hall S, Steed A, Harding S, Westman P, Gogarty J, Katz LM, Bryant M. International forum: donor recruitment research. Vox Sanguinus 93, 250-59 (2007)

Kainthan RK, Janzen J, Kizhakkedathu JN, Devine DV, Brooks DE. Hydrophobically derivatized hyperbranched polyglycerol as human serum albumin substitute. Biomaterials 29, 1693-1704 (2008)

Thon JN, Schubert P, Duguay M, Serrano K, Lin S. Kast J, Devine DV. Comprehensive proteomic analysis of protein changes during platelet storage requires complementary proteomic approaches. Transfusion 48, 425-435 (2008)

Bradley AJ, Read BL, Levin E, Devine DV. Small molecule complement inhibitors cannot prevent the development of the platelet storage lesion. Transfusion 48, 706-14 (2008)

Thon JN, Schubert P, Devine DV. Platelet storage lesion: a new understanding from a proteomic perspective. Transfusion Medicine Reviews 22: 268-79 (2008)

Levin E, Culibrk B, Gyongyossy-Issa MIC, Weiss S, Scammell K, LeFresne W, Jenkins C, Devine DV. Implementation of buffy coat platelet component production: Comparison to platelet-rich plasma platelet production. Transfusion 48: 2331-7 (2008)

Schubert P, Thon JN, Walsh GM, Chen CHI, Moore ED, Devine DV, Kast J. A signalling pathway contributing to platelet storage lesion development: targeting PI3-kinase-dependent Rap1 activation slows storage-induced platelet deterioration. Transfusion (2009) in press.